| Date & Time | Game | Venue |
|---|---|---|
| December 18, 2021 | (1) Sandwich Lady Knights at (0) Nauset/Monomoy Warriors | Charles Moore Arena |
| December 22, 2021 | (0) Scituate Sailors at (6) Sandwich Lady Knights | Gallo Arena |
| December 29, 2021 | (1) Barnstable Red Hawks at (3) Sandwich Lady Knights | Gallo Arena |
| January 12, 2022 | (5) Sandwich Lady Knights at (2) Martha's Vineyard Vineyarders | Martha's Vineyard Arena |
| January 15, 2022 | (2) Falmouth Clippers at (7) Sandwich Lady Knights | Gallo Arena |
| January 17, 2022 | (6) Sandwich Lady Knights at (1) Plymouth Blue Eagles | Armstrong Arena |
| January 19, 2022 | (0) Nantucket Whalers at (6) Sandwich Lady Knights | Gallo Arena |
| January 22, 2022 | (1) Old Rochester Bulldogs at (4) Sandwich Lady Knights | Gallo Arena |
| January 23, 2022 | (2) Canton Bulldogs at (0) Sandwich Lady Knights | Gallo Arena |
| January 26, 2022 | (1) Nauset/Monomoy Warriors at (6) Sandwich Lady Knights | Gallo Arena |
| January 28, 2022 | (1) Sandwich Lady Knights at (2) Notre Dame Academy (Hingham) Cougars | Rockland Arena |
| Jan. 30 Postponed | Dennis-Yarmouth Dolphins at Sandwich Lady Knights
rescheduled from 01/29/22 - POSTPONED AGAIN |
Gallo Arena |
| January 31, 2022 | (5) Sandwich Lady Knights at (1) Dennis-Yarmouth Dolphins | Tony Kent Arena |
| February 02, 2022 | (1) Sandwich Lady Knights at (2) Barnstable Red Hawks | Hyannis Youth and Community Center |
| February 05, 2022 | (0) Old Rochester Bulldogs at (15) Sandwich Lady Knights | Gallo Arena |
| February 06, 2022 | (1) Martha's Vineyard Vineyarders at (6) Sandwich Lady Knights | Gallo Arena |
| February 09, 2022 | (2) Sandwich Lady Knights at (2) Falmouth Clippers | Falmouth Ice Arena |
| February 12, 2022 | (9) Sandwich Lady Knights at (4) Nantucket Whalers | Nantucket Ice Skating Rink |
| February 13, 2022 | (4) Hingham Harborwomen at (0) Sandwich Lady Knights | Gallo Arena |
| February 19, 2022 | (3) Sandwich Lady Knights at (2) Marshfield Rams
Gormley Cup - re-scheduled from 12-31-21 |
Hobomock Arena |
| February 20, 2022 | (0) Dennis-Yarmouth Dolphins at (4) Sandwich Lady Knights | Gallo Arena |
| March 05, 2022 | (2) Burlington Red Devils at (5) Sandwich Lady Knights
Girls Division 2 Tournament |
Gallo Arena |
| March 09, 2022 | (1) Sandwich Lady Knights at (3) Medfield Warriors
Girls Division 2 Tournament |
Gallo Arena |
