| Date & Time | Game | Venue |
|---|---|---|
| December 09, 2021 | (3) Medway/Ashland Mustangs at (2) Newton North/South Tigers | John A. Ryan Arena |
| December 15, 2021 | (3) Westwood Wolverines at (1) Medway/Ashland Mustangs | Blackstone Valley Ice Arena |
| December 18, 2021 | (3) Medway/Ashland Mustangs at (0) Medfield Warriors | Boch Ice Center |
| December 22, 2021 | (7) Medway/Ashland Mustangs at (4) Dover-Sherborn/Hopkinton Raiders | New England Sports Center |
| December 29, 2021 | (3) King Philip Warriors at (2) Medway/Ashland Mustangs
Medway/Ashland Tournament |
Blackstone Valley Ice Arena |
| December 30, 2021 | (1) Natick Red Hawks at (3) Medway/Ashland Mustangs
Medway/Ashland New Year's Invitational |
Blackstone Valley Ice Arena |
| January 05, 2022 | (2) Dedham Marauders at (8) Medway/Ashland Mustangs | Blackstone Valley Ice Arena |
| January 11, 2022 | (2) Medway/Ashland Mustangs at (4) Billerica/Chelmsford Indians | Hallenborg Memorial Pavilion |
| January 12, 2022 | (9) Medway/Ashland Mustangs at (1) Stoughton/Brockston Knight Boxers | Canton Ice House |
| January 15, 2022 | (3) Franklin Panthers at (3) Medway/Ashland Mustangs | New England Sports Center |
| January 19, 2022 | (4) Canton Bulldogs at (1) Medway/Ashland Mustangs | Blackstone Valley Ice Arena |
| January 22, 2022 | (0) MOA Warriors at (5) Medway/Ashland Mustangs | Blackstone Valley Ice Arena |
| January 26, 2022 | (3) Norwood Mustangs at (2) Medway/Ashland Mustangs | Blackstone Valley Ice Arena |
| Jan. 29 Postponed | Medway/Ashland Mustangs at Westwood Wolverines
PPD from 1-29 |
Canton Ice House |
| February 02, 2022 | (5) Medfield Warriors at (4) Medway/Ashland Mustangs | Blackstone Valley Ice Arena |
| February 05, 2022 | (2) Dover-Sherborn/Hopkinton Raiders at (6) Medway/Ashland Mustangs | Blackstone Valley Ice Arena |
| February 09, 2022 | (4) Medway/Ashland Mustangs at (2) Dedham Marauders | Noble & Greenough School |
| February 12, 2022 | (6) Medway/Ashland Mustangs at (0) Norwood Mustangs | The Skating Club of Boston |
| February 14, 2022 | (3) Medway/Ashland Mustangs at (1) Westwood Wolverines | Canton Ice House |
| February 22, 2022 | (5) Medway/Ashland Mustangs at (0) Leominster Blue Devils
Inclusion Cup |
Loring Arena |
| February 23, 2022 | (5) Medway/Ashland Mustangs at (0) Marshfield Rams
Inclusion Cup |
Loring Arena |
| March 03, 2022 | (2) Medway/Ashland Mustangs at (6) Falmouth Clippers
Girls Division 2 Tournament |
Falmouth Ice Arena |
