| Date & Time | Game | Venue |
|---|---|---|
| December 11, 2021 | (3) Marlboro Panthers at (3) Sandwich Blue Knights | Gallo Arena |
| December 12, 2021 | (3) Marlboro Panthers at (1) Longmeadow Lancers
Jim Gormley Cup |
Gallo Arena |
| December 15, 2021 | (6) Marlboro Panthers at (1) Wachusett Mountaineers | NorthStar Ice Sports |
| December 18, 2021 | (6) Marlboro Panthers at (2) Algonquin Titans
Borough's Cup Championship |
NorthStar Ice Sports |
| December 27, 2021 | (6) Marlboro Panthers at (0) Hudson Hawks | New England Sports Center |
| December 29, 2021 | (2) Algonquin Titans at (5) Marlboro Panthers | New England Sports Center |
| Jan. 5 Postponed | Nashoba Wolves at Marlboro Panthers
make-up TBA |
Navin Arena |
| Jan. 8 Postponed | Auburn/Millbury Rockets at Marlboro Panthers
Postponed: Make-Up TBA |
Navin Arena |
| January 10, 2022 | (8) Marlboro Panthers at (3) Leominster Blue Devils | Wallace Civic Center |
| January 15, 2022 | (1) Longmeadow Lancers at (2) Marlboro Panthers | Navin Arena |
| January 17, 2022 | (1) Nashoba Wolves at (9) Marlboro Panthers | Navin Arena |
| January 19, 2022 | (4) Marlboro Panthers at (0) Westboro Rangers | NorthStar Ice Sports |
| January 26, 2022 | (3) Westboro Rangers at (7) Marlboro Panthers | Navin Arena |
| January 28, 2022 | (5) Marlboro Panthers at (2) Auburn/Millbury Rockets | Horgan Skating Arena |
| February 02, 2022 | (2) Algonquin Titans at (3) Marlboro Panthers | Navin Arena |
| February 05, 2022 | (0) Lexington Minutemen at (8) Marlboro Panthers | Navin Arena |
| February 09, 2022 | (1) Hudson Hawks at (9) Marlboro Panthers | NorthStar Ice Sports |
| February 12, 2022 | (0) Groton-Dunstable Crusaders at (5) Marlboro Panthers
Central MA Class A tournament |
Navin Arena |
| February 15, 2022 | (2) Auburn/Millbury Rockets at (7) Marlboro Panthers | Navin Arena |
| February 19, 2022 | (3) Algonquin Titans at (5) Marlboro Panthers
Class A semifinals |
Navin Arena |
| February 23, 2022 | (4) Nashoba Wolves at (3) Marlboro Panthers
Central Mass. Class A Tournament |
New England Sports Center |
| March 03, 2022 | (2) Ludlow Lions at (5) Marlboro Panthers
Boys Division 3 Tournament |
Navin Arena |
| March 07, 2022 | (0) Essex Tech Hawks at (8) Marlboro Panthers
Boys Division 3 Tournament |
Navin Arena |
| March 11, 2022 | (3) Danvers Falcons at (4) Marlboro Panthers
Boys Division 3 Tournament |
Navin Arena |
| March 14, 2022 | (2) Lynnfield Pioneers at (3) Marlboro Panthers
Boys Division 3 Tournament |
Tsongas Center |
| March 20, 2022 | (5) Hanover Hawks at (3) Marlboro Panthers
Boys Division 3 MIAA Championship |
TD Garden |
