| Date & Time | Game | Venue |
|---|---|---|
| December 07, 2021 | Hudson Hawks at Holliston Panthers | New England Sports Center |
| December 15, 2021 | (3) Holliston Panthers at (9) Ashland Clockers | Canton Ice House |
| December 18, 2021 | (2) Holliston Panthers at (12) Medfield Warriors | Pirelli Veterans Arena |
| Dec. 22 Postponed | Hopkinton Hillers at Holliston Panthers
make-up TBA |
Loring Arena |
| December 29, 2021 | (0) Holliston Panthers at (7) Grafton Gators | Buffone Arena |
| December 29, 2021 | (0) Holliston Panthers at (7) Grafton Gators | Buffone Arena |
| December 30, 2021 | (5) Northbridge Rams at (2) Holliston Panthers
Grafton Holiday Tourney |
Buffone Arena |
| January 05, 2022 | (12) Westwood Wolverines at (1) Holliston Panthers | Loring Arena |
| Jan. 8 Postponed | Holliston Panthers at Norwood Mustangs | The Skating Club of Boston |
| Jan. 15 Postponed | Holliston Panthers at Bellingham Blackhawks
make-up TBA |
Pirelli Veterans Arena |
| January 17, 2022 | (7) Dover-Sherborn/Weston Raiders at (3) Holliston Panthers | Loring Arena |
| January 19, 2022 | (8) Norton Lancers at (1) Holliston Panthers | Loring Arena |
| January 26, 2022 | (6) Medway Mustangs at (4) Holliston Panthers | Loring Arena |
| Jan. 29 Postponed | Holliston Panthers at Dover-Sherborn/Weston Raiders
PPD 1-29-22 Make-Up TBA |
Chase Arena |
| February 02, 2022 | (5) Ashland Clockers at (3) Holliston Panthers | Loring Arena |
| February 05, 2022 | (7) Medfield Warriors at (1) Holliston Panthers | Loring Arena |
| February 07, 2022 | (1) Holliston Panthers at (6) Norwood Mustangs | The Skating Club of Boston |
| February 09, 2022 | (0) Holliston Panthers at (7) Hopkinton Hillers | New England Sports Center |
| February 11, 2022 | (2) Dedham Marauders at (1) Holliston Panthers | New England Sports Center |
| February 12, 2022 | (1) Holliston Panthers at (4) Westwood Wolverines | Canton Ice House |
| February 14, 2022 | (4) Holliston Panthers at (5) Dover-Sherborn/Weston Raiders | Chase Arena |
| February 16, 2022 | (6) Norwood Mustangs at (1) Holliston Panthers | Loring Arena |
| February 19, 2022 | (3) Holliston Panthers at (2) Bellingham Blackhawks | Pirelli Veterans Arena |
| February 21, 2022 | (1) Holliston Panthers at (1) Bellingham Blackhawks | Pirelli Veterans Arena |
