| Date & Time | Game | Venue |
|---|---|---|
| December 08, 2021 | Natick Red Hawks at Newton South Lions | John A. Ryan Arena |
| December 14, 2021 | (4) Lowell Red Raiders at (10) Newton South Lions | John A. Ryan Arena |
| December 17, 2021 | (2) Tewksbury Redmen at (1) Newton South Lions | John A. Ryan Arena |
| December 27, 2021 | (0) Newton South Lions at (3) Falmouth Clippers
Ray Kenney Christmas Classic |
Falmouth Ice Arena |
| January 05, 2022 | (4) Newton South Lions at (5) Acton-Boxboro Revolution | Nashoba Valley Olympia |
| January 08, 2022 | (2) Newton South Lions at (0) North Andover Scarlet Knights | Lawrence Valley Forum |
| January 12, 2022 | (0) Concord-Carlisle Patriots at (4) Newton South Lions | John A. Ryan Arena |
| January 15, 2022 | (3) Newton South Lions at (4) Lincoln-Sudbury Warriors | New England Sports Center |
| January 19, 2022 | (3) Newton South Lions at (1) Lowell Red Raiders | Tsongas Center |
| January 22, 2022 | (3) Newton South Lions at (5) Tewksbury Redmen | Breakaway Ice Center |
| January 26, 2022 | (0) Boston Latin Wolfpack at (4) Newton South Lions | John A. Ryan Arena |
| Jan. 29 Postponed | Acton-Boxboro Revolution at Newton South Lions
Postponed: from 1-29-22/ make-up TBD |
John A. Ryan Arena |
| February 02, 2022 | (3) North Andover Scarlet Knights at (2) Newton South Lions | John A. Ryan Arena |
| February 05, 2022 | (3) Newton South Lions at (2) Concord-Carlisle Patriots | Edge Sports Center |
| February 09, 2022 | (2) Lincoln-Sudbury Warriors at (4) Newton South Lions | John A. Ryan Arena |
| February 11, 2022 | (2) Newton South Lions at (0) Boston Latin Wolfpack
re scheduled from 12-22-21 |
Murphy Memorial Rink |
| February 12, 2022 | (1) Newton South Lions at (0) Bridgewater-Raynham Trojans | Bridgewater Ice Arena |
| February 15, 2022 | (2) Newton South Lions at (2) Waltham Hawks
DCL CUP |
Veterans Memorial Rink |
| February 18, 2022 | (2) Westford Academy Ghosts at (4) Newton South Lions
DCL CUP |
John A. Ryan Arena |
| February 19, 2022 | (0) Newton North Tigers at (6) Newton South Lions | John A. Ryan Arena |
| February 21, 2022 | (4) Wellesley Raiders at (4) Newton South Lions | John A. Ryan Arena |
| February 23, 2022 | (0) Acton-Boxboro Revolution at (2) Newton South Lions | John A. Ryan Arena |
| March 03, 2022 | (3) North Attleboro Red Rocketeers at (1) Newton South Lions
Boys Division 2 Tournament |
John A. Ryan Arena |
