| Date & Time | Game | Venue |
|---|---|---|
| December 11, 2021 | (1) Plymouth South Panthers at (4) Dartmouth Indians
Scrimmage |
Hetland Arena |
| December 15, 2021 | (7) Hanover Hawks at (3) Plymouth South Panthers | Armstrong Arena |
| December 18, 2021 | (2) Plymouth South Panthers at (3) Whitman-Hanson Panthers | Rockland Arena |
| December 22, 2021 | (6) Pembroke Titans at (2) Plymouth South Panthers | Armstrong Arena |
| December 27, 2021 | (2) Plymouth South Panthers at (4) Nauset Warriors | Charles Moore Arena |
| Dec. 31 Postponed | Plymouth North Eagles at Plymouth South Panthers | Armstrong Arena |
| January 08, 2022 | (0) Plymouth South Panthers at (6) Quincy Presidents | Quincy Youth Arena |
| January 12, 2022 | (1) Plymouth South Panthers at (6) Plymouth North Eagles | Armstrong Arena |
| January 14, 2022 | (2) St. John Paul II Lions at (7) Plymouth South Panthers | Armstrong Arena |
| January 15, 2022 | (1) Plymouth South Panthers at (4) Duxbury Dragons | The Bog |
| January 19, 2022 | (6) Marshfield Rams at (0) Plymouth South Panthers | Armstrong Arena |
| January 22, 2022 | (1) Plymouth South Panthers at (5) Hanover Hawks | Hobomock Arena |
| January 26, 2022 | (3) Silver Lake Lakers at (2) Plymouth South Panthers | Armstrong Arena |
| February 02, 2022 | (6) Scituate Sailors at (2) Plymouth South Panthers | Armstrong Arena |
| February 05, 2022 | (5) Plymouth South Panthers at (3) Pembroke Titans | Hobomock Arena |
| February 09, 2022 | (5) Quincy Presidents at (2) Plymouth South Panthers | Armstrong Arena |
| February 11, 2022 | (3) Plymouth North Eagles at (4) Plymouth South Panthers | Armstrong Arena |
| February 12, 2022 | (3) Plymouth South Panthers at (2) North Quincy Red Raiders | Quincy Youth Arena |
| February 16, 2022 | (1) North Quincy Red Raiders at (2) Plymouth South Panthers | Armstrong Arena |
| February 19, 2022 | (2) Plymouth South Panthers at (1) Scituate Sailors | Hobomock Arena |
| February 22, 2022 | (2) Plymouth South Panthers at (3) Nauset Warriors | Charles Moore Arena |
| February 23, 2022 | (5) Plymouth South Panthers at (1) St. John Paul II Lions | Kennedy Memorial Skating Rink |
| March 02, 2022 | (0) Plymouth South Panthers at (3) Canton Bulldogs
Boys Division 2 Tournament |
Canton Metropolis Rink |
