| Date & Time | Game | Venue |
|---|---|---|
| December 16, 2021 | (2) Pope Francis Cardinals at (3) Framingham Flyers | Loring Arena |
| December 28, 2021 | (4) Marshfield Rams at (1) Framingham Flyers
MHL Pat Serio Cup |
Loring Arena |
| December 29, 2021 | (2) Saint John's Shrewsbury Pioneers at (1) Framingham Flyers
MHL Pat Serio Cup Consolation Game |
Canton Ice House |
| January 05, 2022 | (2) Framingham Flyers at (3) Walpole Timberwolves | Rodman Arena |
| Jan. 10 Postponed | Hingham Harbormen at Framingham Flyers | Loring Arena |
| January 15, 2022 | (6) Wellesley Raiders at (4) Framingham Flyers | Loring Arena |
| January 19, 2022 | (1) Newton North Tigers at (6) Framingham Flyers | John A. Ryan Arena |
| January 22, 2022 | (2) Framingham Flyers at (3) Milton Wildcats | Ulin Memorial Rink |
| January 23, 2022 | (2) Framingham Flyers at (1) Brookline Warriors | Walter Brown Arena |
| January 26, 2022 | (1) Needham Rockets at (2) Framingham Flyers | Loring Arena |
| January 28, 2022 | (4) Weymouth Wildcats at (4) Framingham Flyers
rescheduled from 01/29/22 |
Loring Arena |
| January 30, 2022 | (1) Framingham Flyers at (4) Reading Rockets
Ed Burns Showcase Quarterfinals |
Ed Burns Arena |
| February 02, 2022 | (3) Brookline Warriors at (7) Framingham Flyers | Loring Arena |
| February 05, 2022 | (2) Framingham Flyers at (2) Natick Red Hawks | Chase Arena |
| February 06, 2022 | (5) Weymouth Wildcats at (6) Framingham Flyers
Ed Burns Showcase Semifinal Round - NHL Rink |
Rodman Arena |
| February 09, 2022 | (3) Braintree Wamps at (2) Framingham Flyers | Loring Arena |
| February 12, 2022 | (3) Framingham Flyers at (3) Wellesley Raiders | Wellesley Sports Center |
| February 13, 2022 | (1) Burlington Red Devils at (2) Framingham Flyers
Ed Burns Coffee Pot Walter Brinn Division - final round game - Blue Rink |
Canton Ice House |
| February 16, 2022 | (1) Newton North Tigers at (10) Framingham Flyers | Loring Arena |
| February 17, 2022 | (0) Natick Red Hawks at (4) Framingham Flyers
re-scheduled from 12-15-21 |
Loring Arena |
| February 19, 2022 | (10) Xaverian Hawks at (3) Framingham Flyers | Loring Arena |
| February 21, 2022 | (6) Framingham Flyers at (0) Medford Mustangs
Cahoon Cup |
Burlington Ice Palace |
| February 23, 2022 | (0) Chelmsford Lions at (2) Framingham Flyers
CAHOON CUP - CHAMPIONSHIP |
Burlington Ice Palace |
| March 03, 2022 | (1) Framingham Flyers at (5) Braintree Wamps
boys Division 1 Tournament |
Zapustas Arena |
