| Date & Time | Game | Venue |
|---|---|---|
| December 16, 2021 | (2) Pope Francis Cardinals at (3) Framingham Flyers | Loring Arena |
| December 18, 2021 | (7) Pope Francis Cardinals at (4) Saint John's Shrewsbury Pioneers | Olympia Center |
| December 22, 2021 | (6) Pope Francis Cardinals at (2) Central Catholic Raiders
PETER FRATES CLASSIC |
Essex Sports Center |
| December 23, 2021 | (2) Pope Francis Cardinals at (3) BC High Eagles
PETER FRATES CLASSIC CHAMPIONSHIP |
Essex Sports Center |
| December 29, 2021 | (4) Pope Francis Cardinals at (2) Braintree Wamps | Zapustas Arena |
| Jan. 8 Postponed | Pope Francis Cardinals at Amherst-Pelham Hurricanes | Collins-Moylan Skating Arena |
| January 15, 2022 | (1) Bridgewater-Raynham Trojans at (4) Pope Francis Cardinals | Olympia Center |
| January 17, 2022 | (1) Reading Rockets at (7) Pope Francis Cardinals | Olympia Center |
| January 19, 2022 | (2) Pope Francis Cardinals at (3) Arlington Spy Ponders | Ed Burns Arena |
| January 22, 2022 | (3) Pope Francis Cardinals at (0) Falmouth Clippers | Falmouth Ice Arena |
| January 27, 2022 | (1) Pope Francis Cardinals at (3) Austin Prep Cougars | Breakaway Ice Center |
| January 30, 2022 | (1) Austin Prep Cougars at (1) Pope Francis Cardinals
re-schedule from 1-29-22 |
Olympia Center |
| February 05, 2022 | (1) Pope Francis Cardinals at (3) Hingham Harbormen | Pilgrim Arena |
| February 06, 2022 | (0) Smithfield (RI) at (5) Pope Francis Cardinals | Olympia Center |
| February 11, 2022 | (1) NORTHWEST CATHOLIC (CT) at (4) Pope Francis Cardinals
POPE FRANCIS INVITATIONAL |
Olympia Center |
| February 12, 2022 | (0) FAIRFELD PREP at (5) Pope Francis Cardinals
POPE FRANCIS INVITATIONAL 10:30 OR 12:30 |
Olympia Center |
| February 17, 2022 | (2) Shrewsbury Colonials at (3) Pope Francis Cardinals | Olympia Center |
| February 19, 2022 | (0) Natick Red Hawks at (5) Pope Francis Cardinals | Olympia Center |
| February 22, 2022 | (0) Catholic Memorial Knights at (4) Pope Francis Cardinals
CARDINAL CLASSIC |
Olympia Center |
| February 23, 2022 | (2) St. Mary's Lynn Spartans at (2) Pope Francis Cardinals
Cardinal Classic-St. Mary's wins in a SO |
Olympia Center |
| March 03, 2022 | (1) Waltham Hawks at (6) Pope Francis Cardinals
Boys Division 1 Tournament |
Olympia Center |
| March 07, 2022 | (0) Pope Francis Cardinals at (3) Braintree Wamps
Boys Division 1 Tournament |
Olympia Center |
