| Date & Time | Game | Venue |
|---|---|---|
| Jan. 11 Postponed | North Middlesex Patriots at Groton-Dunstable Crusaders
make up tbd |
Wallace Civic Center |
| January 18, 2021 | (1) North Middlesex Patriots at (3) Littleton/Bromfield Tigers | Wallace Civic Center |
| Jan. 25 Postponed | North Middlesex Patriots at Littleton/Bromfield Tigers | Wallace Civic Center |
| January 25, 2021 | (4) North Middlesex Patriots at (3) Fitchburg Red Raiders | Wallace Civic Center |
| January 27, 2021 | (0) Lunenburg/Ayer-Shirley Blue Knights at (1) North Middlesex Patriots | Wallace Civic Center |
| January 28, 2021 | (2) Oakmont/Narragansett Spartans at (0) North Middlesex Patriots | Wallace Civic Center |
| January 30, 2021 | (0) Leominster Blue Devils at (1) North Middlesex Patriots | Wallace Civic Center |
| Feb. 3 Postponed | North Middlesex Patriots at Oakmont/Narragansett Spartans | Veterans Arena |
| Feb. 6 Postponed | North Middlesex Patriots at Leominster Blue Devils | Veterans Arena |
| February 10, 2021 | (2) Gardner/Murdock Wildcats at (4) North Middlesex Patriots | Wallace Civic Center |
| February 13, 2021 | (4) Groton-Dunstable Crusaders at (1) North Middlesex Patriots | Wallace Civic Center |
| February 14, 2021 | (2) North Middlesex Patriots at (2) Groton-Dunstable Crusaders | Veterans Arena |
| February 17, 2021 | (2) Oakmont/Narragansett Spartans at (0) North Middlesex Patriots | Wallace Civic Center |
| February 19, 2021 | (3) North Middlesex Patriots at (4) Littleton/Bromfield Tigers | Wallace Civic Center |
